This resource has been produced by LEO Pharma and is intended only for patients in the UK who have been prescribed Anzupgo®▼ (delgocitinib). Side effects reporting information can be found at the bottom of this page. If you are a member of the general public and have not been prescribed this medicine, please visit leo-pharma.co.uk

What is Chronic Hand Eczema?

Hand Eczema is an inflammatory skin condition of the hands and wrists. Chronic Hand Eczema (CHE) is defined as having Hand Eczema for more than 3 months, or if your condition reoccurs twice or more often within 12 months.1

What causes CHE?

Hand Eczema usually has several underlying causes, and it can be difficult to identify exactly why it develops.2

Some risk factors of CHE include:3

  • Childhood eczema
  • Jobs that involve regular exposure to irritants and allergens, such as cleaning and hairdressing
  • A family history of Hand Eczema

How does Chronic Hand Eczema Develop?

It is thought that when you have CHE, your skin barrier doesn’t work as well as it should to keep irritants and allergens out. These factors are able to get into your body more easily and trigger your immune system. By trying to protect you, your immune response causes inflammation, itching, pain, and loss of moisture.2

Skin without CHE4

Skin with CHE4

What is Anzupgo® and how does it work?5

Anzupgo® is a topical cream that contains the active substance delgocitinib.5

Anzupgo® is used in adults to treat moderate to severe CHE in adults for whom topical corticosteroids are inadequate or inappropriate.5

Anzupgo® targets different proteins (enzymes) in the body called JAKs. It works by blocking the activity of four specific JAK enzymes, which helps reduce inflammation and immune responses that cause hand eczema. By suppressing these processes, Anzupgo® can help to improve the condition of the skin and reduce itching and pain. This, in turn, can increase the ability to perform daily activities and may improve your quality of life.5

Possible side effects5

Like all medicines, this medicine can cause side effects, although not everybody gets them. The following side effects have been reported with Anzupgo®:

Common (may affect up to 1 in 10 people):
• Application site reactions (i.e., pain, itching, redness, and tingling)

Reporting of side effects

If you get any side effects talk to your doctor, pharmacist or nurse. You can also report any side effects to the relevant health authorities in the UK. You can report any side effects to the MHRA in the UK.

UK MAT-8262 April 2025

  1. Diepgen TL, et al. J Dtsch Dermatol Ges. 2015;13(1):e1-22
  2. What to Know About Eczema and the Immune System. Healthline. Available at: https://www.healthline.com/health/ severe-eczema/is-eczema-a-sign-of-a-weak-immune-system-your-faqs (Accessed February 2025)
  3. Hand dermatitis (Hand eczema). British Association of Dermatologists. Available at: https://www.bad.org.uk/pils/hand-dermatitis-hand-eczema/ (Accessed February 2025)
  4. Skin Barrier Basics for People With Eczema. National Eczema Association. https://nationaleczema.org/blog/what-is-my-skin-barrier/ (Accessed February 2025)
  5. UK Anzupgo® PIL